Dokter gigi4/30/2023 Thabane has nothing to disclose.Ĭonflict of interest: G.Y.H. Huang has nothing to disclose.Ĭonflict of interest: L. Li has nothing to disclose.Ĭonflict of interest: X. Zhang has nothing to disclose.Ĭonflict of interest: L. Liu has nothing to disclose.Ĭonflict of interest: J. Zhang has nothing to disclose.Ĭonflict of interest: Y. Lip act as the guarantors of this work.Ĭonflict of interest: G. All authors read and approved the final manuscript. Lip: provided professional and statistical support, and made critical revisions. Lip: acquired data, performed analyses and interpretation, and drafted the manuscript. Regular use of glucosamine was significantly related with a 16% lower risk of lung cancer and a 12% decreased risk of lung cancer mortality FootnotesĪuthor contributions: G. A stronger association between glucosamine use and decreased lung cancer risk was observed in participants with a family history of lung cancer when compared with those without a family history.Ĭonclusion Regular use of glucosamine was significantly related with decreased risk of lung cancer and lung cancer mortality, based on data from this nationwide prospective cohort study. Glucosamine use was significantly associated with a decreased risk of lung cancer (hazard ratio (HR) 0.84, 95% CI 0.75–0.92 p<0.001) and lung cancer mortality (HR 0.88, 95% CI 0.81–0.96 p=0.002) in fully adjusted models. During follow-up, 1971 (0.45%) lung cancer events were documented. 82 603 (18.80%) participants reported regular use of glucosamine at baseline. Results 439 393 participants (mean age 56 years 53% females) with a mean follow-up of 11 years were included for analyses. Subgroup analyses and sensitivity analyses were performed to explore the potential effect modifications and the robustness of the main findings. The Cox proportional hazards model was used to assess the relationship between glucosamine use and risk of lung cancer and lung cancer mortality. Methods Participants were enrolled between 20 and followed-up to 2020. We aimed to explore the relationship between use of glucosamine and risk of lung cancer and lung cancer mortality based on data from the large-scale nationwide prospective UK Biobank cohort study. LipĮuropean Respiratory Journal 2022 59: 2101399 DOI: 10.1183/13993003.01399-2021 Abstractīackground Research on glucosamine shows anti-inflammatory and anti-cancer benefits with minimal adverse effects. Guowei Li, Xuhui Zhang, Yingxin Liu, Junguo Zhang, Likang Li, Xin Huang, Lehana Thabane, Gregory Y.H.
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